Μελέτη της έκφρασης του E2F-1 και του CD138 στη χρόνια ηπατική νόσο και το ηπατοκυτταρικό καρκίνωμα
Περίληψη σε άλλη γλώσσα
Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer andusually develops in a background of chronic liver disease. During the multistageprocess of human hepatocarcinogenesis many molecular pathways are disrupted. Thisstudy examines two aspects of hepatocarcinogenesis:a) E2F-1 immunoexpression in chronic viral hepatitis and HCCIntroduction: Transcription factor E2F-1 induces expression of genes governing G1/Sphase transition, DNA synthesis and repair, and apoptosis. Hyposphorylated pRbrepresses E2F-1 action in early G1 phase, while in late G1, pRb hyperphosphorylationleads to E2F-1 release and activation. In vitro studies have shown that E2F-1 may acteither as oncogene or as tumor suppressor gene. To the best of our knowledge, theexpression of E2F-1 in human chronic viral liver disease and HCC, and its role -oncogenic or tumor suppressing - in HCC have not