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ΤΑΜΟΧΙFΕΝ IS WIDELY USED AS ADJUVANT THERAPY IN ALL STAGES OF BREAST CANCER.RECENTLY,INTEREST IS FOCUSED ON ITS PATENTIAL USE AS A PREVENTING AGENT IN WOMEN AT HIGH RISK FOR DEVELOPING THE DISEASE.AS THIS NEW PERSPECTIVE USE ALSO CONCERNS PREMENOPAUSAL WOMEN,A DESIRED PREGNΑNCY FOLLOWING THE DISCONTINUATION OF THE TREATMENT MUST BE TAKEN INTO ACCOUNT.THE PURPOSE OF THE PRESENT STUDY WAS TO INVESTIGATE THE EFFECT OF TAMOXIFEN OF THE FERTILITY OF FEMALE ADULTS WISTAR RATS FOLLOWING THE DISCONTINUATION OF LONG TERM TREATMENT WITH TWO DIFFERENT DOSES OF TAMOXIFEN.68 ADULTS FEMALE RATS WITH A B.W. 147,84+-2,25G WERE DIVIDED INTO 3 GROUPS.ANIMALS IN GROUP A (n=26)_ WERE GIVEN 0,3MG/KG OF TAMOXIFEN P.O.,ANIMALS IN GROUP B (n=30) 3MG/KG AND IN GROUP C(n=12) RPOPYLENE GLUCOLE,FOR 12 WEEKS.ON THE LAST DAY OF TREATMENT A MALE RAT OF PROVEN FERTILITY WAS INTRODUCED INTO EACH CAGE WITH THE FEMALE RATS.TEN DAYS LATERAND WITH A FREQUENCY 14 ANIMALS/WEEK,RATS WERE EUTHANIZED AND THE REMOVED UTER ...
ΤΑΜΟΧΙFΕΝ IS WIDELY USED AS ADJUVANT THERAPY IN ALL STAGES OF BREAST CANCER.RECENTLY,INTEREST IS FOCUSED ON ITS PATENTIAL USE AS A PREVENTING AGENT IN WOMEN AT HIGH RISK FOR DEVELOPING THE DISEASE.AS THIS NEW PERSPECTIVE USE ALSO CONCERNS PREMENOPAUSAL WOMEN,A DESIRED PREGNΑNCY FOLLOWING THE DISCONTINUATION OF THE TREATMENT MUST BE TAKEN INTO ACCOUNT.THE PURPOSE OF THE PRESENT STUDY WAS TO INVESTIGATE THE EFFECT OF TAMOXIFEN OF THE FERTILITY OF FEMALE ADULTS WISTAR RATS FOLLOWING THE DISCONTINUATION OF LONG TERM TREATMENT WITH TWO DIFFERENT DOSES OF TAMOXIFEN.68 ADULTS FEMALE RATS WITH A B.W. 147,84+-2,25G WERE DIVIDED INTO 3 GROUPS.ANIMALS IN GROUP A (n=26)_ WERE GIVEN 0,3MG/KG OF TAMOXIFEN P.O.,ANIMALS IN GROUP B (n=30) 3MG/KG AND IN GROUP C(n=12) RPOPYLENE GLUCOLE,FOR 12 WEEKS.ON THE LAST DAY OF TREATMENT A MALE RAT OF PROVEN FERTILITY WAS INTRODUCED INTO EACH CAGE WITH THE FEMALE RATS.TEN DAYS LATERAND WITH A FREQUENCY 14 ANIMALS/WEEK,RATS WERE EUTHANIZED AND THE REMOVED UTERUS UNDERWENT GROSS AND LIGHT MICROSCOPIC EXAMINATION.NO PREGNANCY WAS NOTICED DURING THE FIRST TWO WEEKS FOLLOWING THE DISCONTINUATION OF TAMOXIFEN IN GROUPS A,B. AT THE 3RD WEEK 2/5 ANIMALS OF GROUP A WERE PREGNANT.AT THE 4TH WEEK 1/5 AND 2/6 ANIMALS OF GROUP A AND B WERE PREGNANT.ALL ANIMALS FROM GROUP C WERE FOUND PREGNANT.AVERAGE NUMBER OF FOETUSES PER ANIMAL WERE 5 FOR GROUP A,2 FOR GROUP B,AND 9 FOR GROUP C.IT IS CONCLUTED THAT ANTIFERTILITY ACTION OF TAMOXIFEN IS REVERSIBLE.TEMPORARY STERILITY AND ITS TIME OF REVERSE ARE NOT DOSE DEPENDENT,AS THE NUMBER OF FOETUSES PER PREGNANCY SEEMS TO BE.
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