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MANAGEMENT OF THE PANCREATIC STUMP, FOLLOWING PANCREATODUODENECTOMY FOR THE MANAGEMENT OF BENIGN OR MALIGNANT COMPLAINTS OF THE HEAD OF THE PANCREAS OR THE DUODENUM, HAS CONSTITUTED THE FIELD OF RESEARCH OF MANY SCIENTISTS, AS PANCREATO- INTESTINAL ANASTOMOSIS HAS BEEN CORRELATED WITH THE HIGH MORBIDITY OF THE METHOD FROM THE BEGINNING. TWO OF THE METHODS OF PANCREATIC STUMP MANAGEMENT ARE LIGATION OF THE PANCREATIC DUCT AND ITS OCCLUSION BY SOME HARDENING, POLYMERIZING SUBSTANCE. THE OBJECT OF THE PRESENT EXPERIMENTAL WORK IS TO COMPARE, AT VARIOUS TIME INTERVALS, THE EFFECTS OF THESE TWO MEANS OF OBSTRUCTION OF THE PANCREATIC DUCT ON THE ENDOCRINE AND EXOCRINE FUNCTION OF THE PANCREAS, AS WELL AS ON THE HISTOPATHOLOGY OF THE ORGAN. THE EXPERIMENTAL ANIMALS, 18 HEALTHY MIXED - BREED DOGS OF BOTH SEXES, WERE DIVIDED INTO TWO GROUPS (A AND B) OF NINE EACH. IN THE GROUP A ANIMALS, LIGATION OF THE PANCREATIC DUCT WAS PERFORMED, WHILE IN THOSE OF GROUP B, ITS OCCLUSION WA ...
MANAGEMENT OF THE PANCREATIC STUMP, FOLLOWING PANCREATODUODENECTOMY FOR THE MANAGEMENT OF BENIGN OR MALIGNANT COMPLAINTS OF THE HEAD OF THE PANCREAS OR THE DUODENUM, HAS CONSTITUTED THE FIELD OF RESEARCH OF MANY SCIENTISTS, AS PANCREATO- INTESTINAL ANASTOMOSIS HAS BEEN CORRELATED WITH THE HIGH MORBIDITY OF THE METHOD FROM THE BEGINNING. TWO OF THE METHODS OF PANCREATIC STUMP MANAGEMENT ARE LIGATION OF THE PANCREATIC DUCT AND ITS OCCLUSION BY SOME HARDENING, POLYMERIZING SUBSTANCE. THE OBJECT OF THE PRESENT EXPERIMENTAL WORK IS TO COMPARE, AT VARIOUS TIME INTERVALS, THE EFFECTS OF THESE TWO MEANS OF OBSTRUCTION OF THE PANCREATIC DUCT ON THE ENDOCRINE AND EXOCRINE FUNCTION OF THE PANCREAS, AS WELL AS ON THE HISTOPATHOLOGY OF THE ORGAN. THE EXPERIMENTAL ANIMALS, 18 HEALTHY MIXED - BREED DOGS OF BOTH SEXES, WERE DIVIDED INTO TWO GROUPS (A AND B) OF NINE EACH. IN THE GROUP A ANIMALS, LIGATION OF THE PANCREATIC DUCT WAS PERFORMED, WHILE IN THOSE OF GROUP B, ITS OCCLUSION WAS EFFECTED BY PROLAMINE (ETHILBLOC). POSTOPERATIVELY AND FOR AN INTERVAL OF BETWEEN 15 DAYS TO 3 MONTHS, WE MONITORED THE EXPERIMENTAL ANIMALS' STOOLS AND THE FLUCTUATIONS IN THE RATES OF GLUCOSE, AMYLASE, INSULIN AND GLUCAGON IN THE BLOOD SERUM. THE EXPERIMENTAL ANIMALS WERE SACRIFICED 15 DAYS, 1 MONTH, OR 3 MONTHS AFTER THE OBSTRUCTION OF THE PANCREATIC DUCT AND THE PANCREAS WAS REMOVED AND SENT FOR HISTOLOGIC EXAMINATION. EDEMA AND INFLAMMATORY CELLULAR INFILTRATION OF THE PANCREAS WERE OBSERVED SOON AFTER THE OBSTRUCTION OF THE (ABSTRACT TRUNCATED)
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