ΑΝΤΙΣΩΜΑΤΑ ΚΑΤΑ ΤΩΝ ΘΥΡΕΟΕΙΔΙΚΩΝ ΚΥΤΤΑΡΩΝ ΕΠΙ ΕΛΛΗΝΩΝ ΔΙΑΒΗΤΙΚΩΝ ΑΣΘΕΝΩΝ.

Abstract

1. Η ΑΝΙΧΝΕΥΣΙΣ ΑΝΤΙΣΩΜΑΤΩΝ ΚΑΤΑ ΤΟΥ ΚΥΤΟΠΛΑΣΜΑΤΟΣ ΤΩΝ ΘΥΡΕΟΕΙΔΙΚΩΝ ΕΠΙΘΗΛΙΑΚΩΝΚΥΤΤΑΡΩΝ ΕΙΣ ΤΟΝ ΟΡΟΝ 300 Φ.Μ. ΚΑΙ 560 ΥΠΟ ΙΝΣΟΥΛΙΝΗΝ ΔΙΑΒΗΤΙΚΩΝ ΑΣΘΕΝΩΝ ΑΜΦΟΤΕΡΩΝ ΤΩΝ ΦΥΛΩΝ, ΕΔΕΙΞΕΝ ΟΤΙ ΟΙ ΔΙΑΒΗΤΙΚΟΙ ΕΜΦΑΝΙΖΟΥΝ ΤΟΙΑΥΤΑ ΑΝΤΙΣΩΜΑΤΑ ΕΙΣΠΟΣΟΣΤΟΝ 6,2% ΕΝΑΝΤΙ 1,7% ΜΑΡΤΥΡΩΝ. 2. Η ΣΤΑΤΙΣΤΙΚΗ ΕΠΕΞΕΡΓΑΣΙΑ ΤΩΝ ΑΝΩΤΕΡΩ ΑΠΟΤΕΛΕΣΜΑΤΩΝ ΕΔΕΙΞΕΝ ΟΤΙ Η ΠΑΡΑΤΗΡΟΥΜΕΝΗ ΜΕΤΑΞΥ ΔΙΑΒΗΤΙΚΩΝ ΑΣΘΕΝΩΝ ΚΑΙ Φ.Μ. ΕΝΤΩ ΣΥΝΟΛΩ ΤΗΣ ΔΙΑΦΟΡΑ ΣΥΧΝΟΤΗΤΟΣ ΚΥΚΛΟΦΟΡΟΥΝΤΩΝ ΑΝΤΙΘΥΡΕΟΕΙΔΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ ΕΙΝΑΙ ΣΤΑΤΙΣΤΙΚΩΣ ΣΗΜΑΝΤΙΚΗΝ ΜΕ ΣΥΝΤΕΛΕΣΤΗΝ Ρ<0,01. 3. ΑΝΑΛΥΣΙΣ ΤΩΝ ΑΠΟΤΕΛΕΣΜΑΤΩΝ ΚΑΤΑ ΦΥΛΟΝ ΔΙΑ ΤΟΥΣ ΑΝΩ ΚΑΙ ΚΑΤΩ ΤΟΥ 40ΟΥ ΕΤΟΣ ΤΗΣ ΗΛΙΚΙΑΣ Φ.Μ. ΚΑΙ ΔΙΑΒΗΤΙΚΟΥΣ ΑΣΘΕΝΕΙΣ ΚΑΤΕΔΕΙΞΕΝ ΟΤΙ ΣΤΑΤΙΣΤΙΚΩΣ ΣΗΜΑΝΤΙΚΗ ΥΠΕΡΟΧΗ ΤΩΝ ΔΙΑΒΗΤΙΚΩΝ ΕΝΑΝΤΙ ΤΩΝ ΜΑΡΤΥΡΩΝ ΕΜΦΑΝΙΖΕΤΑΙ ΜΟΝΟΝ ΕΙΣ ΤΗΝ ΥΠΟΟΜΑΔΑ ΤΩΝ ΓΥΝΑΙΚΩΝ ΗΛΙΚΙΑΣ 40 - 79 ΗΤΙΣ ΥΠΕΡΕΧΕΙ ΤΟΣΟΝ ΤΗΣ ΑΝΤΙΣΤΟΙΧΟΥ ΟΜΑΔΟΣ ΜΑΡΤΥΡΩΝ ΟΣΟΝ ΚΑΙ ΤΗΣ ΑΝΤΙΣΤΟΙΧΟΥ ΗΛΙΚΙΑΣ ΔΙΑΒΗΤΙΚΩΝ ΑΝΔΡΩΝ.

IN THE PRESENT THESIS THE PROBLEM OF THE INCIDENCE OF CIRCULATING ANTIBODIES AGAINST THYROID CYTOPLASM WAS INVESTIGATED IN GREEK PATIENTS WITH DIABETES MELLITUS AND NORMAL CONTROL SUBJECTS. IN THE FIRST PART OF THE PRESENT WORK THE PERTIMENT DATE OF THE LITERATURE CONCERNING THE CURRENT KNOWLEDGE ON DIABETESMELLITUS AND ON AUTOIMMUNE PHENOMENA ASSOCIATED WITH THIS CONDITION ARE REVIEWED PARTICULARLY IN RELATION TO ADDISSONIAN PERNICIOUS ANAEMIA AND THYROID DISEASE. THE SECOND PART OF THIS WORK DEALS WITH THE INVESTIGATION OF A GROUP OFINSULIN - DEPENDENT DIABETIC PATIENTS WHO ARE COMPARED WITH NORMAL CONTROL SUBJECTS MATCHED FOR AGE AND SEX. THE MATERIAL AND METHODS OF STUDY, THE DESCRIPTION AND STATISTICAL ANALYSIS OF THE RESULTS ARE ANALSED IN SEPARATE CHAPTERS. FINALLY THESE RESULTS ARE DISCUSSED IN THE LIGHT OF OTHER RELATED WORKS FROM THE LITERATURE. THE RESULTS AND CONCLUSIONS OF THIS WORK ARE AS FOLLOWS: A)THE INCIDENCE OF ANTIBODIES AGAINST THYROID CYTOPLASM (T.C.A.) IN THE SERUM OF 300 NORMAL CONTROL SUBJECTS AND 560 INSULIN - DEPENDENT DIABETIC PATIENTS OFBOTH SEXES WAS FOUND TO BE 1,7% AND 6,2% RESPECTIVELY. B) STATISTICAL ANALYSIS HAS SHOWN THAT THE DIFFERENCE OF INCIDENCE BETWEEN THE TWO GROUPS IS STATISTICALLY SIGNIFICANT (P<0,01). C) COMPARISON OF THE INCIDENCE OF T.C.A. IN VARIOUS SUBGROUPS OF THE DIABETIC PATIENTS, DIVIDED ACCORDING TO SEX AND AGE (BELOW AND ABOVE 40 YEARS OF AGE) HAS SHOWN THAT ONLY WOMEN OF 40 - 79 YEARS OF AGE HAVE A STATISTICALLY SIGNIFICANT INCREASE OF T.C.A. IN THEIR SERUM WHEN COMPARED (ABSTRACT TRUNCATED)