ΑΝΤΙΣΩΜΑΤΑ ΚΑΤΑ ΤΩΝ ΤΟΙΧΩΜΑΤΙΚΩΝ ΚΥΤΤΑΡΩΝ ΕΠΙ ΕΛΛΗΝΩΝ ΔΙΑΒΗΤΙΚΩΝ ΑΣΘΕΝΩΝ.

Abstract

1. Η ΑΝΙΧΝΕΥΣΙΣ ΑΝΤΙΣΩΜΑΤΩΝ ΚΑΤΑ ΤΩΝ ΤΟΙΧΩΜΑΤΙΚΩΝ ΚΥΤΤΑΡΩΝ ΕΙΣ ΤΟΝ ΟΡΟΝ 300 ΜΑΡΤΥΡΩΝ ΚΑΙ 500 ΔΙΑΒΗΤΙΚΩΝ ΑΣΘΕΝΩΝ ΕΔΕΙΞΕΝ, ΟΤΙ ΟΙ ΔΙΑΒΗΤΙΚΟΙ ΕΜΦΑΝΙΖΟΥΝ ΤΟΙΑΥΤΑΑΝΤΙΣΩΜΑΤΑ ΕΙΣ ΠΟΣΟΣΤΟΝ 14,6% ΕΝΑΝΤΙ 5,7% ΤΩΝ ΜΑΡΤΥΡΩΝ, ΤΗΣ ΔΙΑΦΟΡΑΣ ΟΥΣΗΣ ΣΤΑΤΙΣΤΙΚΩΣ ΣΗΜΑΝΤΙΚΗΣ ΜΕ Ρ<0,01. 2. Η ΣΥΧΝΟΤΗΣ ΑΥΤΗ ΕΠΙ ΜΕΝ ΤΩΝ ΔΙΑΒΗΤΙΚΩΝ ΑΝΔΡΩΝ ΑΝΕΡΧΕΤΑΙ ΕΙΣ 6% ΔΙΑ ΤΟΥΣ ΜΑΡΤΥΡΑΣ ΚΑΙ 11% ΔΙΑ ΤΟΥΣ ΔΙΑΒΗΤΙΚΟΥΣ, ΕΙΣ ΔΕ ΤΑΣ ΓΥΝΑΙΚΑΣ ΑΝΕΡΧΕΤΑΙ ΕΙΣ 5,4% ΕΠΙ ΤΩΝ ΜΑΡΤΥΡΩΝ ΚΑΙ 17,6% ΕΠΙ ΤΩΝ ΔΙΑΒΗΤΙΚΩΝ,ΤΗΣ ΔΙΑΦΟΡΑΣ ΟΥΣΗΣ ΣΤΑΤΙΣΤΙΚΩΣ ΣΗΜΑΝΤΙΚΗΣ ΜΕ Ρ<0,01. 3. ΚΑΤΑ ΤΗΝ ΣΥΓΚΡΙΣΙΝ ΤΗΣ ΣΥΧΝΟΤΗΤΟΣ ΑΝΤΙΣΩΜΑΤΩΝ ΚΑΤΑ ΤΩΝ ΤΟΙΧΩΜΑΤΙΚΩΝ ΚΥΤΤΑΡΩΝ ΕΠΙ ΤΩΝ ΔΙΑΦΟΡΩΝ ΥΠΟΟΜΑΔΩΝ ΔΙΑΒΗΤΙΚΩΝ ΑΣΘΕΝΩΝ ΚΑΤΑ ΦΥΛΟΝ ΚΑΙ ΟΜΑΔΑ ΗΛΙΚΙΩΝ, ΠΑΡΑΤΗΡΕΙΤΑΙ, ΟΤΙ Η ΣΥΧΝΟΤΗΣ ΤΩΝ ΑΝΤΙΣΩΜΑΤΩΝ ΤΟΥΤΩΝ ΕΙΝΑΙ ΙΔΙΑΙΤΕΡΩΣ ΗΥΞΗΜΕΝΗ ΜΕΤΑΞΥ ΤΩΝ ΓΥΝΑΙΚΩΝ ΗΛΙΚΙΑΣ ΑΝΩ ΤΩΝ 40 ΕΤΩΝ.

IN THE PRESENT THESIS THE PROBLEM OF THE INCIDENCE OF CIRCULATING ANTIBODIES AGAINST THE PARIETAL CELL CYTOPLASM WAS STUDIED IN 500 INSULINE - DEPENDENT DIABETIC PATIENTS AND 300 NORMAL CONTROL SUBJECTS MATCHED FOR AGE AND SEX. THE FIRST PART OF THIS WORK DEALS WITH PERTINENT DATE OF THE LITERATURE ON THE HISTOLOGY, PHYSIOLOGY AND AUTOIMMUNITY OF THE GASTRIC MUCOSA AND ITS ABNORMALITIES IN DIABETES MELLITUS. THE AUTOIMMUNE PHENOMENA AGAINST GASTRIC ANTIGENS IN PERNICIOUS ANAEMIA AND DIABETES MELLITUS ARE ALSO REVIEWED IN DETAIL. THE SECOND PART OF THIS THESIS DESCRIBES THE MATERIAL METHODS AND RESULTS OF THE STUDY, WHICH ARE FURTHER STATISTICALLY ANALYSED AND DISCUSSED. SERA TESTED FOR ANTIBODIES TO GASTRIC PARIETAL CELL CYTOPLASM BY THE INDIRECT IMMUNOFLUORESCENCEMETHOD WITH SNAP - FROGEN AIR DRIED SECTIONS OF GASTRIC MUCOSA OBTAINED FROMMICE, AS DESCRIBED BY COONS ET AL. (1942). THE RESULTS AND CONCLUSIONS OF THEPRESENT THESIS ARE AS FOLLOWS: A) THE INCIDENCE OF ANTIBODIES AGAINST PARIETAL CELL CYTOPLASM (P.C.A.) IN THE SERUM OF 500 INSULINE - DEPENDENT DIABETIC PATIENTS AND 300 NORMAL CONTROL SUBJECTS MATCHED FOR AGE WAS 14.6% AND 5.7% RESPECTIVELY, THE DIFFERENCE BETWEEN THE TWO GROUPS BEING STATISTICALLY, SIGNIFICANT (P<0.001). B) COMPARISON OF THE INCIDENCE OF P.C.A. IN VARIOUS SUBGROUPS OF THE DIABETIC PATIENTS, DIVIDED ACCORDING TO AGE AND SEX, HAS SHOWN THAT THESE ANTIBODIES ARE PARTICULARLY INCREASED AMONG PATIENTS ABOVE 40 YEARS OF AGE.(ABSTRACT TRUNCATED)