Συσχέτιση των κριτηρίων του μεταβολικού συνδρόμου με πολυμορφισμούς που αφορούν στον μεταβολισμό των λιπιδίων, την αρτηριακή υπέρταση και τις αγγειακές παθήσεις

Abstract

INTRODUCTION: Metabolic syndrome (MetS) is a cluster of specific relatedclinical disorders whose presence increases the risk of cardiovascular disease. Variousgenetic polymorphisms are implicated in its pathophysiology. This study aims toevaluate the relationship between patients with MetS and healthy subjects, as far asthe allelic frequency of Cholesterol Ester Transfer Protein (CETP) TaqIB and I405V,ATP Binding Cassette Transporter A1 (ABCA1) R219K and Angiotensinogen (AGT)M235T polymorphisms are concerned.MATERIALS AND METHODS: We determined the allelic frequency of CETPTaqIB and I405V, ABCA1 R219K and AGT M235T in 180 MetS patients and 165healthy subjects. For the whole study population values for Total Cholesterol,Triglycerides, High Density Lipoprotein Cholesterol and Low Density LipoproteinCholesterol were collected. Relationships between the two study groups werecalculated.RESULTS: Allele R in ABCA1 R219K polymorphism strongly tends to appear more frequently (p=0.087) in healthy subjects compared to MetS patients. As far as allother studied alleles are concerned, no significant differences between the two studygroups were observed. Also, statistically significant higher levels of Total Cholesteroland Low Density Lipoprotein Cholesterol (p<0.01) were measured in MetS patients.CONCLUSION: Compared to MetS patients, healthy subjects have a strongtendency to carry the R allele of ABCA1 R219K polymorphism, a case that may berelated to more favorable lipid levels in Caucasian populations.