Μελέτη αυτοαντισωμάτων σε διάφορες ηλικιακές oμάδες υγειών γυναικών

Abstract

ΣΤΗΝ ΜΕΛΕΤΗ ΑΥΤΗ ΣΥΓΚΡΙΘΗΚΕ Η ΕΠΙΚΡΑΤΗΣΗ ΤΩΝ ΑΥΤΟΑΝΤΙΣΩΜΑΤΩΝ ΣΕ ΕΝΑ ΥΓΙΗ ΠΛΗΘΥΣΜΟ ΕΓΚΥΩΝ ΓΥΝΑΙΚΩΝ ΣΕ ΣΥΓΚΡΙΣΗ ΜΕ ΜΙΑ ΟΜΑΔΑ ΕΛΕΓΧΟΥ ΜΗ ΕΓΚΥΩΝ, ΚΑΙ ΕΓΙΝΕ ΠΡΟΣΠΑΘΕΙΑ ΝΑ ΚΑΘΟΡΙΣΘΕΙ ΣΕ ΠΟΙΟ ΒΑΘΜΟ

THE PURPOSE OF THIS STUDY WAS TO COMPARE THE PREVANCE OF AUTOANTIBODIES IN A HEALTHY PREGNANT POPULATION TO THAT OF A CONTROL NON-PREGNANT GROUP AND TO DETERMINE WHETHER PREGNANCY INFLUENCES THE AUTOANTIBODY PRODUCTION. OUR RESULTS SHOWED THAT PREGNANT WOMEN HAVE A SIGNIFICANTLY LOWER PREVALENCE OF AUTOANTIBODIES COMPARED TO A HEALTHY MATCHED CONTROL POPULATION. IN OUR STUDY HIGHLY SENSITIVE AND SPECIFIC ΕLISA METHODS AND A WIDELY APPROVED COUNTERIMIN UNOELECTROPHORESIS METHOD WERE USED FOR THE DETECTION OF AUTOANTIBODIES. OUR RESULTS SUGGEST THAT: A)THE PREVALENCE OF AUTOANTIBODIES DECREASE DURING PREGNANCY. B)THE PRESENCE OF ANTI-CARDIOLIPIN ANTIBODIES, ANTI-DS DNA AND ANTI-RO(SS-A) ANTIBODIES IN HEALTHY PREGNANTI WOMEN DOES NOT CORRELATE WITH ANY PREGNANCY RELATED COMPLICATIONS. C)THE DETECTION OF ANTIPHOSPHOLIPID ANTIBODIES IN ESPECIALLY HIGH TITRES MAY BE POSSIBLY CORRELATED TO AN INCREASED RISK OF SPONTANEOUS ABORTIONS. D)UNTIL DEFINITE CONCLUSIONS CAN BE DRAWN, BY THEUSE OF HIGH SENSITIVITY METHODS LIKE THOSE WHICH WERE USED IN THE PRESENT STUDY, THE EVALUATION OF LEVELS OF ANTICARDIOLIPIN ANTIBODIES MAY BE IMPORTANT IN THE OBSERVATION OF PREGNANCY AND ESPECIALLY IN THOSE CASES WITH HIGH RISK OF SPONTANEOUS ABORTIONS. OUR RESULTS ARE IN CONTRAST WITH PREVIOUS REPORTS WHICH SHOWED AN INCREASED PREVALENCE OF AUTOANTIBODY DETECTION IN A "NORMAL" HEALTHY PREGNANT POPULATION.