Ιστική αναζήτηση δεικτών βιολογικής συμπεριφοράς στο καρκίνωμα της ουροδόχου κύστεως

Abstract

Aim: The aim of this study was to investigate the expression of CXCL12, CXCR4and of VEGFR-3 in primary urothelial bladder carcinoma(UCs) and their recurrentin relation to grade and pT status.Material and Method: Immunohistochemistry was applied on 67 primary tumorsand their 67 recurrences.Results: The expression of CXCL12 both in primary cancer(PC) and in recurrentcancer (RC)was positively associated to grade(p<0.0001 and p<0.0001respectively) and pT stage (p=0.001 and p=0.007 respectively).The expression ofCXCR4 both in PC and RC was positively related to grade (p=0.001 and p<0.0001respectively) and pT stage (p=0.008 and p=0.005 respectively).We compared theexpression of CXCL12 and CXCR4 in PC related to RC and we found that both ofthem are more intensive in RC than in PC (p<0.0001 and p<0.0001respectively).CXCL12 was positively correlated with the expression of VEGFR3in RC (p=0.045).Conclusions: CXCL12 and CXCR4 expression was related toadverse prognostic markers at UCs through their association with grade and pTstage both in PC and RC. The axis CXCL12 /CXCR4 may influence the expressionof VEGFR3 in UCs and promote tumour recurrence