Immunohistochemical evaluation of protein expression in membranous glomerulopathy
Abstract
It is now well established that morphological change of podocytes is closely correlated to the development of proteinuria. AIM: The aim of this study was to investigate the role of podocalyxin, a major podocyte protein, in the pathogenesis of glomerulopathies associated primarily with the nephrotic syndrome. Method: Immunohistochemical expression of podoxalyxin has been evaluated in 44 renal biopsies, including normal controls, patients with podocytopathies (minimal change disease/MCD, focal segmental glomerulosclerosis/FSGS) and membranous glomerulopathy (MG). A computerized image analysis program has been used. Statistical analysis was performed using ANOVA and Bonferroni tests. Results: Immunohistochemical expression of podocalyxin has been observed within the podocytes of normal controls. In MCD podocalyxin expression was globally reduced despite the normal appearance of the glomeruli. In FSGS, podocalyxin loss was observed in both the segmental sclerotic and the non-sclerotic area ...
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